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New York/Stuttgart – A new article by Reig et al., published eFirst in Thieme Publishers’ journal Seminars in Liver Disease, discusses the ongoing controversy about treating Hepatitis C patients with direct antiviral agents. The article, which is available to read for free, was also presented at the annual meeting of the European Association for the Study of the Liver (EASL), The International Liver Congress™ 2017, currently taking place in Amsterdam, The Netherlands.

Past success of this treatment method led EASL to recommend using direct antiviral agents to treat almost all Hepatitis C patients, including individuals who had concomitant or prior hepatocellular carcinoma, or any other cancer. This, however, raised controversy when a prior study by Reig et al., published in April 2016, suggested that viral eradication with the new agents could be associated with emergence of recurrent cancer sites in patients previously treated for HCC. The current review updates readers on the topic by summarizing data from recent publications and showing both sides of the argument. The authors also speculate about the mechanisms for cancer emergence and stress the need for further studies.

Reig et al. Liver Cancer Emergence Associated with Antiviral Treatment: An Immune Surveillance Failure? Seminars in Liver Disease, Volume 37, 2017, Thieme Publishers, New York, Stuttgart. 2017


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Thieme Publishing Group is a medical and scientific publishing house employing more than 900 staff and maintaining offices in seven cities, including New York, Delhi, Rio and Stuttgart, Germany. Founded in 1886, the Thieme name has become synonymous with high quality and excellence in online and print publishing. Thieme publishes 150 peer-reviewed journals and more than 450 new books annually. The company has a rapidly growing array of web-based products in medicine and science. State-of-the-art online products include eNeurosurgery, Medlantis, Thieme E-Journals, Thieme Electronic Book Library, the medical student website and Thieme Teaching Assistant, an innovative web-based platform for faculty. For more information about Thieme, please visit

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