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Stuttgart, August 2018 – Science of Synthesis 4.11, the latest release of Thieme’s knowledge base for synthetic methodology, features insights on carbolines and S,S-acetals as well as catalytic reduction. The update consists of a reference library volume as well as a new Knowledge Update, comprising approximately 970 pages of new content.

Knowledge Update starring carbolines and S,S-acetals
Available a mere two weeks after publication of the hard copy, Knowledge Update 2018/2 features a major new chapter on carbolines or pyrido[X,Y-b]indoles by J. A. Joule. The chapter covers the synthesis of all four regioisomeric heterocyclic systems found in both natural products and pharmaceuticals. Highlights of this release also include an introductory chapter on S,S-acetals by T.-Y. Luh and M.-k. Leung describing their use as protecting groups for carbonyl compounds and as alternative functional groups for further transformations. Also included are new knowledge-base chapters on the synthesis of 1,3-dithietanes and 1,3-dithiolanes by T.-Y. Luh, M.-k. Leung, and C.-M. Chou, as the latter are particularly important as masked carbonyl compounds.

The new Knowledge Update volume comprises a total of approximately 500 printed pages representing the most up-to-date and reliable synthetic methods. SOS Knowledge Updates are governed by clearly defined criteria for method selection as well as established editorial processes. Due in great part to this discerning and continuous updating process, SOS prevails as one of the most up-to-date evaluated electronic reference works available, emphasizing the most significant developments in synthetic methodology.

Reference Library continues with catalytic reduction
Following the addition of the first volume with SOS 4.10 in March, SOS 4.11 now expands the Reference Library with Catalytic Reduction in Organic Synthesis, Vol. 2 edited by J. G. de Vries. This volume, like Volume 1, includes the latest developments in the field of catalytic reductions. In addition to covering both heterogeneous and homogeneous catalytic systems, Catalytic Reduction in Organic Synthesis offers a good representation of enantioselective methodology. Comprising 468 printed pages, Volume 2 focuses on carbonyl group reductions, with contributions on the reduction of aldehydes, ketones, and carboxylic acids and derivatives. Also covered are important reductions of specific functional groups including nitriles, azides, and nitro compounds.

With expert evaluated content focusing on subjects of particular current interest, the SOS Reference Library complements the SOS Knowledge Updates to make SOS the complete information source for the modern synthetic chemist.

To get access to Science of Synthesis 4.11 or a free trial please visit:
For more information about Science of Synthesis please visit the website at

About Thieme

Thieme Publishing Group is a medical and scientific publishing house employing more than 1,000 staff and maintaining offices in several cities, including New York, Delhi, Rio and Stuttgart, Germany. Founded in 1886, the Thieme name has become synonymous with high quality and excellence in online and print publishing. Thieme publishes 160 peer-reviewed journals and more than 350 new books annually. The company has a rapidly growing array of web-based products in medicine and science. State-of-the-art online products include Thieme MedOne, Thieme E-Journals, the medical student website, and Thieme MyCourse, an innovative web-based platform for faculty to customize their own course materials. For more information about Thieme, please visit

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