Thieme congratulates this year's winners of the Global Spine Journal Awards. This award is made annually by the Editorial Board to the best Basic Science paper as well as the best Clinical paper. Each year two winners are selected by the Editorial Board and invited to attend the annual Global Spine Congress to receive their awards. Four additional awards will be awarded to our best reviewers of the year.
Best Basic Science Paper 2014:
The Effect of a Cyclooxygenase 2 Inhibitor on Early Degenerated Human Nucleus Pulposus Explants
Bart van Dijk, Esther Potier, Ruud Licht, Laura Creemers, Keita Ito
Study Design Preclinical in vitro culture of human degenerated nucleus pulposus (NP) tissue.
Objective Cyclooxygenase 2 inhibitors (e.g., celecoxib) inhibit prostaglandin E2 (PGE2) production, and they have been shown to upregulate regeneration of articular cartilage. In this study, we developed an explant culture system for use with human tissue and tested the potential of celecoxib.
Methods NP explants were cultured with or without 1 μM of celecoxib and were analyzed at days 0 and 7 for biochemical content (water, sulfated glycosaminoglycans, hydroxyproline, and DNA), gene expression (for disk matrix anabolic and catabolic markers), and PGE2 content.
Results Water and biochemical contents as well as gene expression remained close to native values after 1 week of culture. PGE2 levels were not increased in freshly harvested human NP tissue and thus were not reduced in treated tissues. Although no anabolic effects were observed at the dosage and culture duration used, no detrimental effects were observed and some specimens did respond by lowering PGE2.
Conclusions Human degenerated NP explants were successfully cultured in a close to in vivo environment for 1 week. Further research, especially dosage-response studies, is needed to understand the role of PGE2 in low back pain and the potential of celecoxib to treat painful disks.
Best Clinical Paper 2014:
C3-6 Laminoplasty for Cervical Spondylotic Myelopathy Maintains Satisfactory Long-Term Surgical Outcomes
Hironobu Sakaura, Noboru Hosono, Yoshihiro Mukai, Motoki Iwasaki, Hideki Yoshikawa
Study Design Prospective cohort study.
Objective To clarify long-term surgical outcomes of C3-6 laminoplasty preserving muscles attached to the C2 and C7 spinous processes in patients with cervical spondylotic myelopathy (CSM).
Methods Twenty patients who underwent C3-6 open-door laminoplasty for CSM and who were followed for 8 to 10 years were included in this study. Myelopathic symptoms were assessed using Japanese Orthopaedic Association (JOA) score. Axial neck pain was graded as severe, moderate, or mild. C2-7 angle was measured using lateral radiographs of the cervical spine before surgery and at final follow-up.
Results Mean JOA score before surgery (11.7) was significantly improved to 15.2 at the time of maximum recovery (1 year after surgery), declining slightly to 14.9 by the latest follow-up. Late deterioration of JOA score developed in eight patients, but was unrelated to the cervical spine lesions in each case. No patient suffered from prolonged postoperative axial neck pain at final follow-up. The mean C2-7 angle before surgery (13.8 degrees) significantly increased to 19.2 degrees at final follow-up.
Conclusions C3-6 laminoplasty preserving muscles attached to the C2 and C7 spinous processes in patients with CSM maintained satisfactory long-term neurologic improvement with significantly reduced frequencies of prolonged postoperative axial neck pain and loss of C2-7 angle after surgery.
Best Reviewers 2014:
• Praveen Mummaneni
• Justin Smith
• Han Jo Kim
• Lali Sekhon
AOSpine invites all spine surgeons, researchers, and specialists to submit an abstract for next year's Global Spine Congress that will take place concurrently with the World Forum for Spine Research. The call for abstracts is open until September 15, 2015. The event will take place in Dubai from 13-16 April 2016. Visit the event website to get more information and submit your work: www.gsc2016.org.
Thieme's Atlas of Anatomy titles contain everything students need to successfully tackle the daunting challenges of anatomy. Covering topics such as General Anatomy and the Musculoskeletal System, Neck and Internal Organs, and Head and Neuroanatomy, students can hone in on specific topics and focus on their chosen specialties. All titles integrate stunning, full-color anatomy illustrations with must-know clinical concepts on every page, along with expertly rendered cross-sections, x-rays, and CT and MRI scans to vividly demonstrate clinical anatomy.
As an added bonus, each title contains a scratch-off code granting access to WinkingSkull.com PLUS, featuring over 600 full-color anatomy illustrations and radiographs, "labels-on, labels-off" functionality, and timed self-tests.
The perfect study tools — each book is packed with key information and full-color illustrations!
Key cases for rounds, rotations, and exams
RadCases contains cases selected to simulate everything that you'll see on your rounds, rotations, and exams. RadCases also helps you identify the correct differential diagnosis for each case - including the most critical.
Each RadCases title features 100 carefully selected, must-know cases documented with clear, high-quality radiographs. The organization provides maximum ease of use for self-assessment, including the ‘top 3’ differentials per case to help you hone your diagnostic skills, and examples of critical cases that must be diagnosed immediately to avert potential disaster in daily practice and on exams. Each case begins with the clinical presentation on the right-hand page, followed by imaging findings, differential diagnoses, the definitive diagnosis, essential facts, and more.
Each RadCases title includes a scratch-off code that allows 12 months of access to a searchable online database of all 100 cases from the book plus an additional 150 cases in that book’s specialty–250 cases in total!
Visit RadCases.thieme.com for free sample cases and to experience this dynamic learning tool for yourself!
Head and Neck Imaging
Once a year medical students who wish to become board certified neurosurgeons study to pass both a written and oral examination administered by the American Board of Neurological Surgery (ABNS). To help medical students prepare for this examination, Thieme has published the following neurosurgery references and board review books.
An ideal resource for board exam preparation, this review distills the essentials of neurosurgery in a user-friendly question and answer format. Divided into three main sections, this text presents a comprehensive collection of cases covering intracranial pathology, spinal and peripheral nerve pathology, and neurology.
The second edition of Comprehensive Neurosurgery Board Review contains all the information you need to prepare for the American Board of Neurological Surgery (ABNS) written examination. Authored by a team of expert clinicians and neurosurgery trainees who earned top scores on their exams, this edition distills the current knowledge of the neurosciences and essential information for clinical practice.
For two decades, Handbook of Neurosurgery -- now in a fully updated seventh edition -- has been an invaluable companion for every neurosurgery resident and nurse, as well as neurologists and others involved in the care of patients with brain and spine disorders. Dr. Greenberg's classic text covers the breadth of neurosurgery and its allied specialties and provides the latest information on anatomy and physiology, differential diagnosis, and currently accepted principles of clinical management.
The only portable handbook on operative techniques in neurosurgery, this step-by-step guide offers unparalleled coverage of every major operative procedure seen in daily practice. Concise chapters hold key clinical information on indications, preoperative planning, intraoperative technique, postoperative care, and complications, with insights and advice from renowned experts representing every main specialty in the field.
The author interviews section is a collection of videos where our authors explain their books in great detail. Often leaders in their respective fields, our author interviews provide valuable insights into the brilliant minds that make Thieme Medical Publishers a leader in STM publishing.
Gordon Baltuch - author of Operative Techniques in Epilepsy Surgery
Robert Jackler - author of Skull Base Surgery and Neurotology
Allen Maniker - author of Operative Exposures in Peripheral Nerve Surgery
Jesse Jupiter - author of AO Manual of Fracture Management: Elbow & Forearm
Professor Philipp Lobenhoffer - author of Osteotomies around the Knee
James P. Stannard - editor-in-chief of Journal of Knee Surgery
Alexander Vaccaro - author of Spine Surgery: Tricks of the Trade
Jeffrey Wang - editor-in-chief of Global Spine Journal
Theodore K. Schwartz - author of Endoscopic Pituitary Surgery
Manuel Bernal-Sprekelsen - author of Complications in Otolaryngology-Head and Neck Surgery
Roy R. Casiano - author of Endoscopic Sinonasal Dissection Guide
Paul J. Donald - author of The Difficult Case in Head and Neck Cancer Surgery
Eric Smouha & Dennis Bojrab - authors of Cholesteatoma
James Duncavage and Samuel Becker - authors of The Maxillary Sinus: Medical and Surgical Management
Andrew Blitzer - author of Neurologic Disorders of the Larynx
Richard A. Pollock - author of Craniomaxillofacial Buttresses: Anatomy and Operative Repair
Steven Meyers - author of MRI of Bone and Soft Tissue Tumors and Tumorlike Lesions
Vikram S. Dogra - author of Musculoskeletal Ultrasound with MRI Correlations
David Kennedy - author of Rhinology: Diseases of the Nose, Sinuses and Skull Base
Aldo Stamm - author of Transnasal Endoscopic Skull Base and Brain Surgery